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DMSO is a substrate for chloroperoxidase.

J Geigert, S K DeWitt, S L Neidleman

Biochemical and Biophysical Research Communications

|October 14, 1983

Summary

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Dimethyl sulfoxide (DMSO) is not inert in haloperoxidase reactions. It forms halosulfoxide, sulfone, and halosulfone, impacting biological significance.

Area of Science:

Biochemistry
Organic Chemistry

Background:

Dimethyl sulfoxide (DMSO) is a common nonaqueous solvent used in enzymatic reactions.
Haloperoxidases are enzymes that catalyze halogenation reactions.

Purpose of the Study:

To investigate the reactivity of dimethyl sulfoxide under chloroperoxidase reaction conditions.
To identify potential byproducts formed from DMSO during these reactions.

Main Methods:

Chloroperoxidase-catalyzed reactions were performed using DMSO as a solvent.
Reaction products were analyzed to identify any DMSO derivatives.

Main Results:

Dimethyl sulfoxide was found to be reactive under chloroperoxidase conditions.
Formation of halosulfoxide, sulfone, and halosulfone from DMSO was observed.

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Conclusions:

DMSO is not an inert solvent in chloroperoxidase-catalyzed reactions.
The formation of these byproducts has potential biological implications that warrant further discussion.