Role of nigral dopamine in amphetamine-induced locomotor activity

Dopamine (100 micrograms) injected into the substantia nigra pars reticulata of rats pretreated with the monoamine oxidase inhibitor, pargyline, resulted in a stimulation of locomotor activity. Bilateral injection of the dopamine antagonist haloperidol (5 micrograms) into the substantia nigra pars reticulata resulted in a reduction of the locomotor activity evoked by a low dose of amphetamine (1.25 mg/kg s.c.). These results suggest that the release of dopamine from nigral dendrites is involved in amphetamine-induced locomotor activity.