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Compensatory thyroid hyperplasia in hemithyroidectomized Snell dwarf mice.

A Lewiński, A Bartke, N K Smith

    Endocrinology
    |December 1, 1983
    PubMed
    Summary
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    Compensatory thyroid hyperplasia (CTH) occurs after hemithyroidectomy (HEMITX) in both normal and Snell dwarf mice. This suggests extrapituitary factors, likely neural pathways, regulate CTH, even without pituitary hormones.

    Area of Science:

    • Endocrinology
    • Cell Biology
    • Physiology

    Background:

    • Thyroid follicular cell proliferation is crucial for maintaining thyroid hormone homeostasis.
    • Compensatory thyroid hyperplasia (CTH) is a known response to reduced thyroid mass.
    • Snell dwarf mice lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH).

    Purpose of the Study:

    • To investigate the role of extrapituitary factors in compensatory thyroid hyperplasia (CTH).
    • To compare CTH in Snell dwarf mice and normal mice following hemithyroidectomy (HEMITX).

    Main Methods:

    • Hemithyroidectomy (HEMITX) was performed on Snell dwarf mice (dw/dw) and phenotypically normal mice (?/+).
    • The colchicine metaphase-arrest technique was used to assess mitotic activity.

    Related Experiment Videos

  • Mitotic rates in the remaining thyroid lobe were measured 48 hours post-surgery.

    • Main Results:

    • A significant increase in mitotic activity was observed in the remaining thyroid lobe of both normal and dwarf mice after contralateral HEMITX (P < 0.001).
    • This indicates the presence of compensatory thyroid hyperplasia (CTH) in both groups.
    • The results demonstrate CTH occurs independently of pituitary hormones like TSH, GH, and PRL.

    Conclusions:

    • Extrapituitary factors, likely involving neural pathways, play a significant role in regulating compensatory thyroid hyperplasia (CTH).
    • This finding is particularly relevant in Snell dwarf mice, which exhibit deficiencies in multiple pituitary hormones.
    • CTH is not solely dependent on pituitary-Tropic hormone stimulation.