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Transmissible murine colonic hyperplasia.

S W Barthold, G L Coleman, R O Jacoby

    Veterinary Pathology
    |March 1, 1978
    PubMed
    Summary
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    A Citrobacter freundii variant caused transmissible murine colonic hyperplasia in mice. This condition, marked by severe mucosal hyperplasia and mitotic activity, led to high mortality in suckling mice.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pathology

    Background:

    • Citrobacter freundii is a Gram-negative bacterium.
    • Colonic hyperplasia is an increase in the number of cells in the colon.

    Purpose of the Study:

    • To investigate the effects of a specific Citrobacter freundii variant on murine colonic tissue.
    • To characterize the development and severity of transmissible murine colonic hyperplasia.

    Main Methods:

    • Inoculation of suckling and adult mice with a variant of Citrobacter freundii.
    • Observation and assessment of colonic mucosal hyperplasia over a 2-3 week period.
    • Evaluation of mortality rates and associated pathological changes in suckling mice.

    Main Results:

    Related Experiment Videos

    • Both suckling and adult mice developed transmissible murine colonic hyperplasia of similar severity.
    • Peak hyperplasia occurred 2-3 weeks post-inoculation, followed by regression.
    • Suckling mice exhibited high mortality due to secondary inflammatory and erosive changes.
    • Severe hyperplasia involved significant mitotic activity throughout the colonic crypts and surface mucosa.

    Conclusions:

    • The studied Citrobacter freundii variant induces transmissible murine colonic hyperplasia.
    • Age influences mortality outcomes, with suckling mice being more vulnerable.
    • The hyperplasia is characterized by significant cellular proliferation in the colonic mucosa.