Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iodine-induced changes in thyroglobulin half-sized subunits.

G Palumbo, M F Tecce

    Experientia
    |November 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: Siltuximab as a first-line therapy for idiopathic multicentric Castleman disease: a retrospective analysis based on the SiMuLa study of the Italian regional network.

    Frontiers in oncology·2026
    Same author

    Siltuximab as a first-line therapy for idiopathic multicentric Castleman disease: a retrospective analysis based on the SiMuLa study of the Italian regional network.

    Frontiers in oncology·2026
    Same author

    Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology.

    NeuroImage·2025
    Same author

    Outcomes and prognostic indicators in daratumumab-refractory multiple myeloma: a multicenter real-world study of elotuzumab, pomalidomide, and dexamethasone in 247 patients.

    ESMO open·2025
    Same author

    Predictors of protective behaviors among American travelers to the 2009 Hajj.

    Journal of epidemiology and global health·2024
    Same author

    Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression.

    British journal of haematology·2023
    Same journal

    On the influence of aneurine on the formation of nitrogenic bacterial nodites.

    Experientia·2010
    Same journal

    Around the biochemical activities of the flavobacterium.

    Experientia·2010
    Same journal

    Electron microscopic investigations on cellulose fibers after treatment with ultrasound.

    Experientia·2010
    Same journal

    Reviving scientific life in Hungary.

    Experientia·2010
    Same journal

    A new method for the production of deoxy sugars.

    Experientia·2010
    Same journal

    About the aneine content of the irritated and irritated frog nerves after poisoning with mono-iodoacetic acid.

    Experientia·2010
    See all related articles

    Researchers separated and analyzed thyroglobulin subunits. The faster subunit contained significantly more iodine than the slower one, despite similar peptide and carbohydrate composition.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Endocrinology

    Background:

    • Thyroglobulin (Tg) is a key protein in thyroid hormone synthesis.
    • Understanding the structure and composition of Tg subunits is crucial for comprehending thyroid function.

    Purpose of the Study:

    • To analyze the biochemical and compositional differences between the two half-sized subunits of 19 S thyroglobulin.

    Main Methods:

    • Separation of 19 S thyroglobulin into its constituent half-sized subunits.
    • Analysis of peptide composition.
    • Assessment of carbohydrate content.
    • Quantification of iodine levels in each subunit.

    Main Results:

    • Both subunits exhibited identical peptide composition and carbohydrate content.

    Related Experiment Videos

  • A significant difference in iodine levels was observed, with the faster electrophoretic subunit containing approximately three times more iodine than the slower subunit.

    • Conclusions:

    • The differential iodine content suggests a functional or structural specialization between the two thyroglobulin subunits.
    • Further investigation is warranted to elucidate the implications of this iodine heterogeneity for thyroid hormone production.