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Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations
Experientia
|November 15, 1983
Abstract:
In rats, chronic infusion of alpha-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined. There were no gross pharmacological effects associated with this depletion.