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Related Experiment Videos

[Thioamide derivatives with gastro-protective activity].

E Bousquet, F Guerrera, M A Siracusa

    Il Farmaco; Edizione Scientifica
    |October 1, 1983
    PubMed
    Summary

    Researchers synthesized novel 3-aryl-prop-2-enthioamide derivatives and tested their gastro-protective effects in rats. The N,N-dimethylamino derivative demonstrated the highest gastro-protective activity in this series.

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    Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

    Canadian journal of surgery. Journal canadien de chirurgie·2022

    Area of Science:

    • Medicinal Chemistry
    • Pharmacology

    Context:

    • Gastrointestinal disorders represent a significant health burden.
    • Developing effective gastro-protective agents is crucial for managing conditions like ulcers and gastritis.

    Purpose:

    • To synthesize and evaluate a series of 3-aryl-prop-2-enthioamide derivatives for their gastro-protective potential.
    • To identify the most potent compound within the synthesized series for further investigation.

    Summary:

    • A novel series of 3-aryl-prop-2-enthioamide derivatives was successfully synthesized.
    • These compounds were assessed for their ability to protect the gastric lining in a rat model.
    • The N,N-dimethylamino substituted derivative (comp. II) exhibited superior gastro-protective activity compared to other analogs.

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    Impact:

    • This study identifies a promising lead compound for the development of new gastro-protective drugs.
    • The findings contribute to the understanding of structure-activity relationships in 3-aryl-prop-2-enthioamide derivatives for gastrointestinal protection.