Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Connective tissue in aging lung.

L Andreotti, A Bussotti, D Cammelli

    Gerontology
    |January 1, 1983
    PubMed
    Summary

    Lung aging alters collagen and elastin content, with collagen decreasing and the collagen/elastin ratio declining. These biochemical changes align with observed morphological and functional shifts in the aging lung.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Facial Mask and Plexiglass Box: a critical overview on the current strategies to protect patients from COVID-19 infection.

    Journal of biological regulators and homeostatic agents·2021
    Same author

    Influence of prebiotic administration on inflammatory and glycaemic markers in type-2 diabetes.

    Journal of biological regulators and homeostatic agents·2020
    Same author

    The alteration of stress-related physiological parameters after probiotics administration in oral surgeons with different degrees of surgical experience.

    La Clinica terapeutica·2020
    Same author

    Gait changes following direct versus contralateral strength training: A randomized controlled pilot study in individuals with multiple sclerosis.

    Gait & posture·2020
    Same author

    First report of anti-TIF1γ dermatomyositis in a patient with myelodysplastic syndrome.

    Reumatismo·2017
    Same author

    Circulating T cells to infliximab are detectable mainly in treated patients developing anti-drug antibodies and hypersensitivity reactions.

    Clinical and experimental immunology·2016

    Area of Science:

    • Pulmonary Medicine
    • Biochemistry
    • Gerontology

    Background:

    • The aging lung undergoes significant structural and functional changes.
    • Understanding the biochemical alterations in lung tissue with age is crucial for pulmonary health research.

    Purpose of the Study:

    • To quantify collagen, elastin, and structural glycoproteins in aging human lungs.
    • To correlate age-related biochemical changes with lung parenchyma volume and weight.

    Main Methods:

    • Postmortem lung tissue analysis from 21 subjects (aged 15-83).
    • Measurement of collagen, elastin, and glycoproteins per unit volume of fixed lung parenchyma.
    • Standardized inflation pressure (25 cm H2O) to ensure consistent tissue volume.

    Main Results:

    • Lung parenchyma volume/weight ratio increased significantly with age.
    • Collagen content and the collagen/elastin ratio decreased significantly with age.
    • Elastin content showed no significant correlation with age.

    Conclusions:

    • Biochemical changes in lung tissue, including decreased collagen, are characteristic of lung aging.
    • Findings support the agreement between biochemical, morphological, and functional data in the senile lung.

    Related Experiment Videos