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Exocrine pancreatic function in the elderly.

L Gullo, P Priori, C Daniele

    Gerontology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Aging does not significantly impact exocrine pancreatic function. Studies show elderly individuals maintain pancreatic bicarbonate and enzyme output comparable to younger controls, with minimal enzyme reduction in a few cases.

    Area of Science:

    • Gastroenterology
    • Gerontology
    • Physiology

    Background:

    • Exocrine pancreatic function is crucial for digestion.
    • The effects of aging on pancreatic function require further investigation.

    Purpose of the Study:

    • To assess pancreatic bicarbonate and enzyme output in elderly versus young individuals.
    • To determine if aging significantly influences exocrine pancreatic function.

    Main Methods:

    • Continuous intravenous infusion of secretin (1 CU/kg X h) and cerulein (100 ng/kg X h).
    • Measurement of pancreatic bicarbonate and enzyme output.
    • Comparison between 25 elderly subjects and 30 young controls.

    Main Results:

    • Most elderly subjects exhibited pancreatic outputs within the normal range observed in young controls.

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  • A slight reduction in enzyme output was noted in only 3 elderly individuals.

    • Conclusions:

    • Exocrine pancreatic function, including bicarbonate and enzyme output, is largely preserved in aging.
    • Aging does not appear to be a significant factor in the decline of exocrine pancreatic function.