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Related Experiment Videos

Haemodialyser reuse: impact on function and biocompatibility.

N A Hoenich, S R Johnston, P Buckley

    The International Journal of Artificial Organs
    |September 1, 1983
    PubMed
    Summary

    Reusing haemodialysers with Cuprophan membranes maintains functional performance but may increase blood loss. Biocompatibility is altered upon reuse, particularly without rinsing, impacting haemodialysis leucopenia.

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    Area of Science:

    • Biomaterials Science
    • Nephrology
    • Medical Device Engineering

    Background:

    • Haemodialysers are critical for renal replacement therapy.
    • Cuprophan membranes are commonly used in haemodialysers.
    • Understanding haemodialyser reuse is important for cost-effectiveness and resource management.

    Purpose of the Study:

    • To evaluate the functional performance and biocompatibility of disposable haemodialysers with Cuprophan membranes after reuse.
    • To compare reuse techniques (manual and automated) with first-time use.
    • To assess the impact of reuse on haemodialysis leucopenia.

    Main Methods:

    • Functional performance tests (small molecule clearance, ultrafiltration, blood loss) were conducted.
    • Biocompatibility was assessed by monitoring haemodialysis leucopenia.

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  • Haemodialysers were reused using manual and automated methods.
  • Comparison between first use and reused haemodialysers was performed.

    • Main Results:

    • Functional performance, including small molecule clearance and ultrafiltration, remained unchanged after reuse.
    • Blood loss increased significantly in reused haemodialysers compared to first use.
    • Biocompatibility was altered upon reuse, specifically if sodium hypochlorite rinsing was not employed.
    • Haemodialysis leucopenia was affected by reuse, depending on the rinsing process.

    Conclusions:

    • Haemodialyser reuse with Cuprophan membranes is feasible regarding functional performance, with the caveat of increased blood loss.
    • The biocompatibility of reused haemodialysers is influenced by the reuse protocol, particularly the rinsing process.
    • Careful consideration of rinsing protocols is necessary to mitigate altered biocompatibility and potential effects on haemodialysis leucopenia.