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Anterograde amnesia with oral lorazepam
The Journal of Clinical Psychiatry
|October 1, 1983
Summary
Oral lorazepam, a common daytime tranquilizer, can cause memory loss. This study found it significantly impaired delayed word recall in healthy subjects, indicating amnestic effects.
Area of Science:
- Pharmacology
- Neuroscience
- Cognitive Psychology
Background:
- Intravenous benzodiazepines are known to cause anterograde amnesia.
- The amnestic effects of orally administered benzodiazepines, particularly lorazepam, require further investigation.
Purpose of the Study:
- To assess the effects of a single oral dose of lorazepam on memory recall.
- To determine if oral lorazepam administration results in anterograde amnesia.
Main Methods:
- A single 2 mg oral dose of lorazepam was administered to 6 healthy subjects.
- Immediate and delayed word list recall were compared between the lorazepam group and a placebo control group (6 subjects).
Main Results:
- No significant difference in immediate word list recall was observed between groups.
- Lorazepam significantly impaired delayed word list recall compared to placebo.
Conclusions:
- Oral administration of lorazepam can induce amnestic effects.
- Lorazepam may hinder memory consolidation, impacting delayed recall.
- These findings suggest caution when using lorazepam as a daytime tranquilizer due to potential memory impairment.