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Related Experiment Videos

Dyphylline versus theophylline: a double-blind comparative evaluation.

C T Furukawa, G G Shapiro, W E Pierson

    Journal of Clinical Pharmacology
    |October 1, 1983
    PubMed
    Summary

    Dyphylline demonstrated effectiveness in blocking exercise-induced bronchospasm (EIB) compared to placebo. However, its therapeutic benefit was significantly smaller than theophylline, suggesting further research for optimal dosing.

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    Area of Science:

    • Pediatric Pulmonology
    • Clinical Pharmacology
    • Exercise Physiology

    Background:

    • Exercise-induced bronchospasm (EIB) is a common condition in adolescents.
    • Current treatments aim to prevent airway narrowing during physical activity.
    • Dyphylline and theophylline are bronchodilators with potential for EIB management.

    Purpose of the Study:

    • To evaluate the efficacy of three different doses of dyphylline against placebo and theophylline in blocking EIB.
    • To compare the dose-response relationship of dyphylline for EIB prevention.
    • To assess the safety profile of dyphylline in adolescent patients.

    Main Methods:

    • A randomized, double-blind, placebo-controlled study involving 20 adolescent patients (12-17 years).
    • Participants received dyphylline (10, 15, or 20 mg/kg), theophylline (6 mg/kg), or placebo on separate days before an exercise challenge.

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  • Pulmonary function tests, including PEFR, FEV1, and FEF25-75%, were measured to assess EIB.

    • Main Results:

    • Dyphylline showed a dose-dependent relationship in preventing declines in PEFR, FEV1, and FEF25-75% compared to placebo.
    • The 15 and 20 mg/kg doses of dyphylline significantly reduced EIB symptoms compared to placebo.
    • Dyphylline's efficacy was approximately one-half to one-third of that achieved with theophylline, with less frequent tremor side effects.

    Conclusions:

    • Dyphylline offers a therapeutic benefit over placebo for blocking EIB in adolescents.
    • The observed benefit of dyphylline is modest when compared to theophylline.
    • Further studies are warranted to determine optimal dyphylline dosages for maximizing its effectiveness in EIB management.