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Bacterial meningitis in Nottingham.

P Ispahani

    The Journal of Hygiene
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Bacterial meningitis mortality varied by causative organism, with pneumococcal meningitis being the deadliest. Factors like age and consciousness level significantly impacted patient prognosis in this 1974-1980 study.

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    Area of Science:

    • Clinical Microbiology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Bacterial meningitis remains a significant cause of morbidity and mortality worldwide.
    • Understanding the causative agents and prognostic factors is crucial for effective patient management.
    • Previous studies have highlighted variations in outcomes based on pathogen and patient demographics.

    Purpose of the Study:

    • To analyze the distribution of bacterial pathogens causing meningitis.
    • To identify factors influencing mortality rates across different age groups.
    • To assess the impact of pre-admission antibiotic therapy on prognosis and diagnosis.

    Main Methods:

    • Retrospective review of 171 bacterial meningitis cases admitted to Nottingham hospitals (January 1974 - June 1980).

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  • Analysis of causative organisms, patient demographics, clinical presentation, laboratory findings, and outcomes.
  • Statistical assessment of factors associated with mortality and diagnostic challenges.

    • Main Results:

    • Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae were responsible for 69% of proven cases.
    • Overall mortality was 26%, with the highest (53%) in pneumococcal meningitis and lowest (0%) in meningococcal meningitis.
    • Poor prognostic indicators included age extremes (<2 months or >40 years), altered consciousness, high CSF protein, and positive blood culture; prior antibiotics did not affect prognosis but altered lab findings.

    Conclusions:

    • Causative agents and age significantly influence bacterial meningitis outcomes.
    • Early recognition of prognostic factors is vital for clinical decision-making.
    • Diagnostic capabilities remain effective despite pre-admission antibiotic use.