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Related Experiment Videos

Cutaneous blood flow in psoriasis.

P Klemp, B Staberg

    The Journal of Investigative Dermatology
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Cutaneous blood flow (CBF) is significantly elevated in both psoriatic lesions and normal-appearing skin of psoriasis vulgaris patients compared to healthy individuals. This study quantifies increased blood flow in psoriasis using 133Xe clearance.

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    Area of Science:

    • Dermatology
    • Physiology
    • Medical Imaging

    Background:

    • Psoriasis vulgaris is a chronic inflammatory skin condition.
    • Altered cutaneous microcirculation is implicated in psoriasis pathogenesis.
    • Quantifying blood flow changes is crucial for understanding disease mechanisms.

    Purpose of the Study:

    • To investigate and quantify cutaneous blood flow (CBF) in patients with psoriasis vulgaris.
    • To compare CBF in psoriatic lesions, normal-appearing psoriatic skin, and healthy control skin.
    • To analyze the relationship between skin composition and blood flow in psoriasis.

    Main Methods:

    • Utilized the 133Xe epicutaneous labeling technique to measure the disappearance rate of Xenon-133.
    • Calculated CBF in 20 patients with psoriasis vulgaris and 10 healthy subjects.

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  • Analyzed psoriatic skin biopsies to determine water, lipid, and protein content for partition coefficient estimation.

    • Main Results:

    • Mean CBF in untreated psoriatic skin was 63.5 ml/100 g/min, significantly higher than in normal subjects (6.3 ml/100 g/min).
    • Normal-appearing skin in psoriasis patients showed elevated CBF (11.0 ml/100 g/min) compared to controls.
    • Psoriatic skin exhibited reduced water content and increased lipids and proteins.

    Conclusions:

    • Psoriasis vulgaris is characterized by significantly increased cutaneous blood flow in both lesional and non-lesional skin.
    • The observed changes in skin composition may influence blood flow measurements.
    • Findings highlight the hyperemic nature of psoriatic skin, suggesting microcirculatory dysregulation.