Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in immune function in patients receiving natural leukocyte interferon.

A E Maluish, J R Ortaldo, S A Sherwin

    Journal of Biological Response Modifiers
    |January 1, 1983
    PubMed
    Summary

    This study investigated human lymphoblastoid interferon in cancer patients, finding it had limited impact on immune cell activity. While some patients showed increased monocyte antitumor effects, overall immune responses were not consistently enhanced.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Natural killer activity: the definition of a function rather than a cell type.

    Immunology today·2014
    Same author

    Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance.

    Journal of leukocyte biology·2008
    Same author

    Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells.

    Journal of immunology (Baltimore, Md. : 1950)·2001
    Same author

    The ever-expanding Ly49 gene family: repertoire and signaling.

    Immunological reviews·2001
    Same author

    Activating Ly-49 NK receptors: central role in cytokine and chemokine production.

    Journal of immunology (Baltimore, Md. : 1950)·2001
    Same author

    Class I MHC-binding characteristics of the 129/J Ly49 repertoire.

    Journal of immunology (Baltimore, Md. : 1950)·2001

    Area of Science:

    • Immunology
    • Oncology
    • Virology

    Background:

    • Interferons (IFNs) are crucial signaling proteins in the immune system.
    • Lymphoblastoid interferon (IFN-Ly) is a type of IFN produced by lymphoblastoid cells.
    • Investigating IFN-Ly's therapeutic potential in disseminated malignancies is important.

    Purpose of the Study:

    • To evaluate the efficacy and immunomodulatory effects of human lymphoblastoid interferon in patients with advanced cancers.
    • To assess the impact of escalating doses of IFN-Ly administered via intravenous (IV) infusion or intramuscular (IM) injection on immune functions.

    Main Methods:

    • Forty patients with refractory disseminated malignancies received daily escalating doses (0.1-50 x 10^6 U) of highly purified IFN-Ly for up to 5 weeks.
    • Treatment was administered via 6-hour IV infusion or IM injection.

    Related Experiment Videos

  • Immune functions, including natural killer (NK) cell activity, monocyte-mediated cytotoxicity, and lymphoproliferative responses, were extensively monitored.

    • Main Results:

    • No sustained elevation in natural killer (NK) cell activity was observed.
    • Elevated monocyte-mediated antitumor cytostatic activity was noted in approximately 30% of patients.
    • Lymphoproliferative responses to mitogens and mixed leukocyte culture were generally depressed.

    Conclusions:

    • Human lymphoblastoid interferon showed limited sustained immunomodulatory effects in patients with disseminated malignancies.
    • The observed antitumor activity in a subset of patients warrants further investigation.
    • IFN-Ly administration may lead to complex alterations in immune responses, including suppression of certain lymphocyte functions.