High-performance liquid chromatographic determination of cyproheptadine hydrochloride in tablet formulations

A high-performance liquid chromatographic method is described which determines cyproheptadine hydrochloride in tablet formulations. Tablets were dissolved in water-acetonitrile (50:50) and analyzed using an octadecylsilane column with a mobile phase of 85% acetonitrile and 15% of an aqueous solution of 0.01 M 1-octanesulfonic acid, 0.5% triethylamine, and 1% acetic acid using UV absorbance detection at 280 nm.