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Updated: Aug 31, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Maintenance-dose prediction based on a single determination of concentration: general applicability to
Abstract:
A general approach to the selection of the maintenance dose (Dm) required to give a desired steady-state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two-compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants alpha and beta, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.
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