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High-performance liquid chromatographic stability-indicating assay for naphazoline and tetrahydrozoline in ophthalmic
Journal of Pharmaceutical Sciences
|November 1, 1983
Abstract:
A high-performance liquid chromatographic (HPLC) analysis for tetrahydrozoline and naphazoline in ophthalmic solutions is presented. The analysis allows a more reproducible, direct stability-indicating assay than the colorimetric methods generally employed. The HPLC system is so designed that a variety of ophthalmic solutions containing either naphazoline or tetrahydrozoline can be analyzed concomitantly.