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Side effects of desensitization for allergy--a general practice survey
The Journal of the Royal College of General Practitioners
|October 1, 1983
Summary
House dust mite desensitization can cause severe side effects, including anaphylaxis. A survey of general practitioners found one additional death reported, highlighting the need for careful patient monitoring during this allergy treatment.
Area of Science:
- Allergy and Immunology
- General Practice
- Pharmacovigilance
Background:
- House dust mite (HDM) desensitization is a treatment for allergic rhinitis.
- Anaphylaxis is a rare but serious potential side effect of allergen immunotherapy.
- A recent fatal case of anaphylaxis prompted an investigation into desensitization practices.
Purpose of the Study:
- To assess the experience and reported side effects of house dust mite desensitization among general practitioners.
- To understand the prevalence of desensitization use and associated adverse events in a specific region.
Main Methods:
- A questionnaire survey was distributed to general practitioners in Hampshire.
- Data were collected on the usage patterns and perceived side effects of desensitization treatments.
- Response rate from 695 doctors was 65% (452 valid questionnaires).
Main Results:
- 14% of surveyed doctors did not use desensitization.
- The majority of prescribers used five or fewer courses per year.
- Two deaths, including the index case, were reported in association with desensitization.
Conclusions:
- While generally used cautiously, house dust mite desensitization carries a risk of severe adverse events, including fatalities.
- Further vigilance and reporting of side effects are crucial for patient safety in allergen immunotherapy.