[Clinico-pathological studies on multiple colorectal cancer]

Area of Science:

• Gastroenterology
• Surgical Oncology
• Oncology

Context:

• This study examines 743 patients with colorectal cancer over 21 years, focusing on 52 cases of double cancer, excluding familial polyposis.
• Investigates the association between adenomas and multiple colorectal carcinomas.
• Analyzes outcomes for synchronous and metachronous double colorectal cancers.

Purpose:

• To evaluate the association of adenomas in multiple versus single colorectal carcinomas.
• To assess the surgical resectability and patient outcomes for synchronous and metachronous double colorectal cancers.
• To determine prognostic factors influencing survival in patients with double colorectal cancers.

Summary:

• A higher incidence of adenomas was observed in patients with multiple colorectal carcinomas compared to single carcinomas.
• Synchronous multiple colorectal tumors, even with advanced and early-stage cancers, showed no recurrence or mortality, except when multiple advanced cancers were present.
• The stomach was the most frequently involved organ in double cancer cases (66.7%).
• Early-stage synchronous double colorectal cancers were associated with long-term survival.
• Metachronous double colorectal cancers, even with early primary detection, had poor outcomes if the second cancer was advanced.

Impact:

• Early detection and management of synchronous double colorectal cancers, particularly in early stages, can lead to favorable long-term survival.
• Highlights the importance of considering adenomas in the context of multiple colorectal carcinomas.
• Provides insights into the surgical management and prognostic implications of double colorectal cancers, including common co-occurring sites like the stomach.