Chromatographic and spectral properties of some aryl-substituted phencyclidine analogs

As part of a search for phencyclidine (PCP) antagonists, a series of eleven aryl-substituted PCP analogs were prepared and characterized. TLC and GC elution profiles of these derivatives are described in a number of systems allowing for the tentative identification of the PCP analogs. Further, MS, NMR, UV/vis and IR spectral tabulations are provided. Correlation of chromatographic character with physical organic structure parameters, such as those of Hammet, showed good predictability.