A biophysical model for interaction of cells with a surface coat (glycocalyx). I. Electrostatic interaction profile

A model of the primary stage of cell-cell interaction is assumed, including not only the classical electrostatic and electrodynamic energies in the sense of DLVO theory but also steric interaction energy, the energy of specific and non-specific bonds and the energy due to changes of surface potential. Furthermore, in this paper, we exploit recent advances in the understanding of the structure of the cell surface (glycocalyx), assuming the fixed electrostatic charges (dissociated groups of the glycocalyx), to be space charge densities and the glycocalyx itself to be an adsorption layer. In this first part the profile of the electrostatic potential between two cells is calculated on the basis of the linear Poisson-Boltzmann equation (analytical integration) and discussed in dependence on charge densities of the glycocalyx, the separation distance between cells and the ionic strength of the suspension medium.