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Dynamic behavior of cyclic enzyme systems.

M Okamoto, K Hayashi

    Journal of Theoretical Biology
    |October 21, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Computer simulations reveal that cyclic enzyme systems, sharing substrates or cofactors, exhibit catastrophic dynamic behavior. This occurs due to external input changes, even without allosteric regulation.

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    Area of Science:

    • Biochemistry
    • Enzyme kinetics
    • Systems biology

    Background:

    • Cyclic enzyme systems involve two enzymes sharing a substrate or cofactor.
    • Understanding their dynamic behavior is crucial for comprehending complex biological pathways.

    Purpose of the Study:

    • To investigate the dynamic behavior of cyclic enzyme systems using computer simulation.
    • To identify conditions leading to non-linear dynamic characteristics in these systems.

    Main Methods:

    • Computer simulations were employed to model cyclic enzyme systems.
    • The study focused on systems where two enzymes share a common substrate or cofactor.

    Main Results:

    • The dynamic characteristics of cyclic enzyme systems were found to display catastrophic behavior.

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  • This behavior was observed in response to specific changes in external input.
  • Catastrophic behavior occurred without the necessity of allosteric regulation.

    • Conclusions:

    • Cyclic enzyme systems can exhibit abrupt and significant changes in behavior.
    • External factors can destabilize these systems, leading to 'catastrophic' shifts.
    • The findings highlight the inherent sensitivity of cyclic enzyme dynamics.