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Interaction of theophylline with erythromycin base in a patient with seizure activity
Pediatrics
|December 1, 1983
Insights
Erythromycin can cause theophylline toxicity in pediatric patients with asthma, leading to seizures. Close monitoring of theophylline levels is crucial when these medications are co-prescribed.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Clinical Toxicology
Background:
- Theophylline is a common medication for managing chronic asthma in pediatric patients.
- Erythromycin is an antibiotic frequently prescribed for respiratory infections like bronchitis.
Observation:
- A pediatric patient on monitored theophylline doses developed toxicity after starting erythromycin base.
- The observed toxicity manifested as seizure activity.
Findings:
- Co-administration of erythromycin and theophylline significantly increases the risk of theophylline toxicity.
- Erythromycin inhibits the metabolism of theophylline, leading to elevated serum concentrations.
Implications:
- Healthcare providers must closely monitor serum theophylline levels in pediatric patients receiving concurrent erythromycin therapy.
- This interaction necessitates careful consideration of medication regimens to prevent adverse events and ensure patient safety.
Abstract:
A pediatric patient who was taking carefully monitored doses of theophylline for chronic asthma, was placed on erythromycin base for bronchitis. She subsequently developed theophylline toxicity which caused her to experience seizure activity. Any patient taking a theophylline preparation who is then placed on ANY of the available erythromycin compounds must have close monitoring of serum theophylline levels.