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Haemostatic abnormalities in systemic lupus erythematosus.

D D Gladman, M B Urowitz, E C Tozman

    The Quarterly Journal of Medicine
    |January 1, 1983
    PubMed
    Summary

    Coagulation abnormalities are common in systemic lupus erythematosus (SLE) patients, affecting 57%. These frequent hemostatic defects, including low antithrombin III and fibrinogen, did not correlate with disease activity or clinical bleeding.

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    Area of Science:

    • Hematology
    • Rheumatology
    • Immunology

    Background:

    • Systemic lupus erythematosus (SLE) is an autoimmune disease with complex pathophysiology.
    • Hemostatic system abnormalities are an under-recognized aspect of SLE management.
    • Understanding coagulation profiles in SLE is crucial for patient care.

    Purpose of the Study:

    • To investigate the prevalence and types of hemostatic abnormalities in SLE patients.
    • To determine if these abnormalities correlate with disease activity or clinical manifestations.
    • To establish a baseline for further research into thrombosis and bleeding risks in SLE.

    Main Methods:

    • Coagulation studies were conducted on 112 consecutive SLE patients.
    • Hemostatic function was assessed for various parameters, including platelet counts, anticoagulants, antithrombin III, and fibrinogen.

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  • Results were compared to 50 healthy volunteers and analyzed for correlations with SLE disease activity and clinical features.

    • Main Results:

    • 57% of SLE patients exhibited hemostatic abnormalities.
    • Common findings included thrombocytopenia (16%), circulating anticoagulants (16.9%), decreased antithrombin III (24%), and fibrinogen abnormalities (23%).
    • Multiple abnormalities were found in 25 patients; no abnormalities were seen in controls. No significant correlation was found between hemostatic defects and SLE disease activity or specific clinical manifestations.

    Conclusions:

    • Hemostatic dysfunction is highly prevalent in SLE patients.
    • The presence of these abnormalities does not appear to be linked to disease activity or specific clinical symptoms.
    • Further investigation is warranted to understand the clinical implications of these findings, particularly regarding thrombotic events.