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Updated: Aug 19, 2026

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
Published on: August 31, 2016
[Change in the relative number of hematopoietic stem cells during long-term irradiation with different dose
Abstract:
In this work a model is proposed describing inactivation of colony-forming haemopoietic stem cells as a function of time during long-term irradiation within a wide range of dose-rates (from 0.01 to 100 Gy/day). There was a good agreement between theoretical and experimental data on the number of stem cells altered by irradiation of mice within the indicated range of dose-rates. It was shown that specific rate of cell division increased and the duration of the mitotic cycle decreased (from 98 h to 7 h) with increasing dose-rate by 3, or more, orders.
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