[Change in the pH of Chinese hamster cells following irradiation with different doses]

Changes in the intracellular pH cf Chinese hamster cells irradiated with different doses were investigated. Using the fluorescence method it was shown that irradiation of cultured cells with doses inducing reproductive death (2.5-20 Gy) caused a temporary shift of pH by 0.4-0.5 units toward the alkaline region. After a dose of 500 Gy, inducing interphase death of cells, the alkalization of the intracellular medium was more pronounced (greater than or equal to 8.0) and persisted for 1.5 h.