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Related Experiment Videos

Determining reference ('normal') limits in medicine: an application.

P D Bezemer, J C Netelenbos, C Mulder

    Statistics in Medicine
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Establishing reliable laboratory reference limits is crucial for diagnostics. This study highlights the importance of considering patient status (in- vs. out-patients), age, and sex for accurate reference intervals.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Diagnostic Reference Intervals

    Background:

    • Reference limits are essential for interpreting laboratory test results.
    • Methodological considerations in establishing reference limits are often overlooked.
    • The utility of reference limits is primarily in the initial diagnostic phase.

    Purpose of the Study:

    • To assess reference limits for eight routine laboratory tests.
    • To emphasize methodological issues in establishing reference limits.
    • To propose improvements for defining and reporting reference limits.

    Main Methods:

    • Study conducted at the Academic Hospital of the Free University, Amsterdam.
    • Inclusion of selected patients as the reference population.

    Related Experiment Videos

  • Analysis of factors influencing reference limits, including patient status, age, and sex.

    • Main Results:

    • Significant differences observed between in-patients and out-patients.
    • A minimum reference sample size of 100 is recommended for reliability.
    • Percentiles are suggested for more flexible interpretation than fixed limits.

    Conclusions:

    • Patient status (in- vs. out-patient), age, and sex are critical factors for reference limits.
    • A sample size of at least 100 is necessary for robust reference limit determination.
    • Reporting laboratory results with percentiles enhances diagnostic flexibility.