Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scanning electron microscopy in cytodiagnosis.

W Domagala, L G Koss

    Scanning Electron Microscopy
    |January 1, 1983
    PubMed
    Summary

    Scanning electron microscopy (SEM) can aid in cancer diagnosis by identifying irregular microvilli on cells. However, SEM is unlikely to replace traditional methods as a primary diagnostic tool for cytology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The impact of an expanded genetic testing program and selective oophorectomy on the incidence of ovarian cancer in West Pomerania.

    Clinical genetics·2016
    Same author

    Concordance of KRAS mutation status between luminal and peripheral regions of primary colorectal cancer. A laser-capture microdissection-based study.

    Polish journal of pathology : official journal of the Polish Society of Pathologists·2016
    Same author

    Immunohistochemical analysis of steroid receptors in ovaries of postmenopausal women--effects of aging and hormone status.

    Histology and histopathology·2010
    Same author

    Automated image analysis in the diagnosis of bladder cancer.

    Applied optics·2010
    Same author

    Harry m. Zimmerman, m.d. (1901-1995).

    The American journal of pathology·2009
    Same author

    The mystery of chromosomal translocations in cancer.

    Cytogenetic and genome research·2007

    Area of Science:

    • Cytopathology
    • Electron Microscopy
    • Oncology

    Background:

    • Cytodiagnosis relies on microscopic examination of cells.
    • Scanning electron microscopy (SEM) offers high-resolution surface imaging.
    • The diagnostic utility of SEM in various cancers requires detailed investigation.

    Purpose of the Study:

    • To evaluate the diagnostic significance of SEM in cytodiagnosis.
    • To identify characteristic SEM features of cancer cells.
    • To assess the role of SEM in conjunction with light microscopy for cancer diagnosis.

    Main Methods:

    • Application of SEM to cytodiagnostic samples from various organs (uterine cervix, esophagus, stomach, bronchus, urinary bladder).
    • Analysis of cells from effusions and fine needle aspiration biopsies.
    • Comparison of SEM findings with light microscopy.

    Main Results:

    • Irregular, pleomorphic microvilli (MV) were a consistent feature of cancer cells observed via SEM.
    • SEM provided additional morphological data valuable for preselected cases.
    • SEM may aid in assessing tumor differentiation and screening high-risk patients.

    Conclusions:

    • SEM is a valuable adjunct to light microscopy in specific cytodiagnostic scenarios.
    • SEM's unique morphological insights can support cancer diagnosis and assessment.
    • SEM is not recommended as a standalone primary tool for cytologic cancer diagnosis.

    Related Experiment Videos