Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation of haplotype frequencies.

N E Morton, S P Simpson, R Lew

    Tissue Antigens
    |October 1, 1983
    PubMed
    Summary

    Maximum likelihood estimates for haplotype frequencies in multilocus systems can be zero, which is genetically problematic. This study introduces improved estimation methods to address these limitations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Validation and comparison of quality-of-life measures for topical 5-fluorouracil treatment: results from a randomized controlled trial.

    Clinical and experimental dermatology·2017
    Same author

    Detection of linkage between quantitative trait loci and restriction fragment length polymorphisms using inbred lines.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Correction: Detection of linkage between quantitative trait loci and restriction fragment length polymorphism using inbred lines.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Improvement in precision of counting actinic keratoses.

    The British journal of dermatology·2013
    Same author

    Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMR1 haplotypes.

    Human mutation·2007
    Same author

    Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region.

    Annals of human genetics·2006

    Area of Science:

    • Population genetics
    • Statistical genetics
    • Bioinformatics

    Background:

    • Haplotype frequency estimation is crucial for understanding genetic variation.
    • Maximum likelihood (ML) methods are widely used but can yield zero estimates for rare haplotypes in multilocus systems.
    • Zero estimates are often genetically unrealistic and hinder downstream analyses.

    Purpose of the Study:

    • To identify and discuss the estimation problems associated with maximum likelihood in multilocus haplotype frequency calculations.
    • To derive and propose preferable estimation methods that overcome the limitations of standard ML approaches.

    Main Methods:

    • Analysis of maximum likelihood estimation procedures for multilocus haplotype frequencies.
    • Development of alternative statistical methods for haplotype frequency estimation.

    Main Results:

    • Identified that maximum likelihood estimates frequently result in zero frequencies for certain haplotypes.
    • Demonstrated the genetic unacceptability of zero estimates in multilocus systems.
    • Derived alternative estimation strategies that provide more biologically plausible results.

    Conclusions:

    • Standard maximum likelihood estimation is inadequate for multilocus haplotype frequencies due to zero estimates.
    • The proposed preferable estimation methods offer a more robust and genetically sound approach for analyzing complex genetic data.

    Related Experiment Videos