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Related Experiment Videos

Red cell esterase-d-polymorphism in the Veneto population.

P Cortivo, F Breda, G Ongaro

    Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine
    |May 29, 1978
    PubMed
    Summary
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    Red cell Esterase D (EsD) enzyme polymorphism was analyzed in 630 individuals from Veneto, Italy. Gene frequencies align with European populations, confirming Mendelian co-dominant inheritance for EsD.

    Area of Science:

    • Genetics
    • Biochemistry
    • Population Studies

    Background:

    • Esterase D (EsD) is a red blood cell enzyme with known genetic polymorphisms.
    • Understanding EsD gene frequencies is important for population genetics and human genetic diversity studies.

    Purpose of the Study:

    • To determine the gene frequencies of red cell Esterase D (EsD) in the Veneto population of Italy.
    • To compare EsD gene frequencies with other European and Italian populations.
    • To confirm the inheritance pattern of EsD.

    Main Methods:

    • Cellogel electrophoresis was used to analyze red cell EsD phenotypes in 630 individuals and 102 mother/child pairs.
    • Zymogram patterns were compared with horizontal starch-gel electrophoresis.
    • Gene frequencies were calculated and compared with existing population data.

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    Main Results:

    • No differences were observed between Cellogel and horizontal starch-gel electrophoresis for EsD zymogram patterns.
    • Observed EsD gene frequencies were EsD1 = 0.8556 and EsD2 = 0.1444.
    • These frequencies are similar to other European populations and nearly identical to other Italian populations.

    Conclusions:

    • The study confirms Mendelian co-dominant inheritance for Esterase D.
    • The EsD gene frequencies in the Veneto population are consistent with broader European patterns.
    • Cellogel electrophoresis is a reliable method for EsD phenotyping.