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[Hemosorption as a method of 5-fluorouracil elimination]
Voprosy Onkologii
|January 1, 1983
Summary
Activated carbon effectively removes 5-fluorouracil from biological fluids. Hemosorption significantly reduced drug concentration, though therapeutic doses increased circulating drug levels in dogs.
Area of Science:
- Pharmacology
- Biomedical Engineering
Context:
- 5-fluorouracil (5-FU) is a widely used chemotherapy agent with a narrow therapeutic index.
- Efficient methods for 5-FU removal from biological fluids are crucial for managing toxicity.
- Activated carbon hemoperfusion is a potential extracorporeal detoxification technique.
Purpose:
- To evaluate the efficacy of ADB-13 ty uncoated activated carbon for 5-fluorouracil (5-FU) removal in vitro and in vivo.
- To assess the impact of perfusion parameters on 5-FU sorption capacity.
- To investigate the hemosorptive effect and pharmacodynamics of 5-FU in a canine model.
Summary:
- In vitro and in vivo studies demonstrated that ADB-13 ty uncoated activated carbon exhibits high sorptive capacity for 5-FU.
- Dynamic perfusion trials showed a significant reduction in drug concentration, with a 584-fold decrease after 40 minutes at 100 ml/min.
- In dogs, maximal hemosorptive effect was observed with lethal doses (100 mg/kg), while therapeutic doses (30 mg/kg) led to increased circulating drug levels.
Impact:
- This study highlights the potential of activated carbon hemoperfusion as an effective method for 5-FU detoxification.
- Findings provide crucial data for optimizing hemoperfusion protocols in clinical settings.
- Further research may explore the application of this technique for managing 5-FU overdose or toxicity.