[Lymphocyte changes in chronic posthemorrhagic iron-deficiency anemia].

Area of Science:

• Hematology
• Immunology
• Nutritional Science

Background:

• Chronic anemia, particularly posthemorrhagic iron deficiency anemia, affects various bodily systems.
• Peripheral blood lymphocytes play a crucial role in immune responses.
• Understanding lymphocyte function in anemia is vital for managing complications.

Purpose of the Study:

• To investigate morphological and functional deviations in peripheral blood lymphocytes of patients with chronic posthemorrhagic iron deficiency anemia.
• To assess the impact of iron deficiency on lymphocyte blast transformation.
• To evaluate the effect of iron-containing preparations on lymphocyte function.

Main Methods:

• Examination of ninety patients with chronic posthemorrhagic iron deficiency anemia.
• Assessment of peripheral blood lymphocyte morphology and function.
• Measurement of lymphocyte blast transformation under phytohemagglutinin stimulation.
• Evaluation of T-lymphocyte levels and immunoglobulins.
• Analysis of lymphocyte mitochondria ultrastructure.

Main Results:

• Reduced blast transformation of lymphocytes was observed in patients with iron deficiency anemia.
• Treatment with iron-containing preparations led to improvement in lymphocyte blast transformation.
• No reduction in T-lymphocytes or immunoglobulins was found.
• No changes in the ultrastructure of lymphocyte mitochondria were established.

Conclusions:

• Iron deficiency significantly impacts lymphocyte blast transformation, a key immune function.
• Iron supplementation can restore impaired lymphocyte function in patients with iron deficiency anemia.
• The findings suggest a link between iron deficiency, altered lymphocyte function, and increased susceptibility to infections.