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Related Experiment Videos

[Alternatives to glycoside therapy?].

F Kubicek

    Wiener Klinische Wochenschrift
    |September 16, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Digitalis glycosides, despite their narrow therapeutic range, remain crucial for heart failure and arrhythmias. Research is ongoing for safer alternatives, but digitalis is still the primary choice, with careful dosing essential.

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    Deutsche medizinische Wochenschrift (1946)·1978

    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Narrow therapeutic range of digitalis glycosides necessitates alternative medication.
    • Digitalis intoxication poses significant risks, driving research for safer options.

    Purpose:

    • To review current therapeutic strategies for heart failure and arrhythmias.
    • To discuss the role of vasodilators and positive inotropic agents.
    • To highlight the continued importance of digitalis and its appropriate use.

    Summary:

    • Vasodilators are used as adjuvant or alternative therapy by reducing cardiac pre- and afterload.
    • Catecholamines are the primary positive inotropic substances for acute myocardial failure.
    • Oral positive inotropic agents are under investigation, but not yet routine.
    • Digitalis remains the drug of choice for impaired contractility and supraventricular tachyarrhythmias.

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  • Dosage adjustment based on lean body mass is critical.
  • Digitoxin is preferred in renal insufficiency, particularly in the elderly.

    • Impact:

    • Informs clinical practice regarding digitalis use and alternatives.
    • Highlights the need for precise dosing and patient selection.
    • Guides future research in cardiovascular pharmacotherapy.