[Diagnosis of thrombosis with indium-111 labeled thrombocytes]

The distribution pattern of 111In-labelled autologous platelets was investigated in 50 patients. Imaging was performed with a scintillation camera connected to a computer system. 20 patients suffering from obliterative arterial disease showed a normal platelet distribution. Endothelial lesions after arteriography were found in 6 out of 10 patients. 15 of 20 patients with suspected venous thrombosis showed local platelet deposition. 10 of these patients with local platelet depositions were investigated by phlebography. Positive findings (fresh thrombi) were found in 8 patients. Optimum results were obtained by injecting platelets distal to the venous thrombus. Signs of thrombosis are interruption of blood flow, collateral formation and platelet deposition. This new method offers possibilities of radioisotopic diagnosis of parietal thrombus and venous thrombosis despite anticoagulation or fibrinolysis.