[Ampicillin associated acute interstitial nephritis with renal insufficiency--case report]

It is reported on a 20-year-old male patient, in whom during the treatment of a streptococcal infection with ampicillin an exanthem and an acute interstitial nephritis with acute renal insufficiency appeared. The temporary connection between the application of the medicament and the occurrence of the clinical symptoms and the sensitization to ampicillin proved by the lymphocyte transformation test speak for an ampicillin-induced interstitial nephritis. The discontinuation of the treatment with ampicillin and the application of prednisolone led to a complete involution of the clinical picture. Since ampicillin is frequently used in the clinic one should take into consideration in the indication that possibly an acute renal insufficiency may appear due to an acute interstitial nephritis.