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Related Experiment Videos

[Conditioned reflex switching-over in the rat after temporary functional decortication].

N I Nezlina, G D Kuznetsova

    Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova
    |September 1, 1983
    PubMed
    Summary

    Spreading depression temporarily disrupted conditioned switching-over in rats. This disruption was more severe and prolonged after posterior hypothalamus lesions, indicating the cerebral cortex

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    Neuroscience and behavioral physiology·2007

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Neurophysiology

    Background:

    • Conditioned switching-over involves establishing distinct behavioral responses to the same stimulus under varying conditions.
    • The role of the cerebral cortex and subcortical structures in complex learned behaviors is a key area of research.

    Purpose of the Study:

    • To investigate the impact of spreading depression on conditioned switching-over in rats.
    • To examine how prior lesions to the posterior hypothalamus affect the brain's response to spreading depression in the context of learned behaviors.

    Main Methods:

    • Elaboration of an alimentary instrumental reflex and an electro-defensive avoidance reflex to the same auditory stimulus in rats.
    • Induction of spreading depression using bilateral KCl application to the dura mater.

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  • Electrolytic lesions of the posterior hypothalamus in a subset of animals.

    • Main Results:

    • A single application of spreading depression disrupted conditioned switching-over for 2-3 days.
    • In animals with prior posterior hypothalamus lesions, spreading depression caused a deeper and longer-lasting disturbance of conditioned switching-over.
    • These findings suggest that complex conditioned activities are more vulnerable to transient cortical dysfunction, particularly following CNS injury.

    Conclusions:

    • Spreading depression significantly impairs complex learned behaviors like conditioned switching-over.
    • The integrity of subcortical structures, such as the posterior hypothalamus, plays a crucial role in the brain's resilience to cortical disruption.
    • Compensatory recovery mechanisms after CNS lesions may increase susceptibility to further insults impacting higher cognitive functions.