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Budd-Chiari syndrome in a patient with Sjögren's syndrome

H Matsuura, T Matsumoto, T Hashimoto

    The American Journal of Gastroenterology
    |December 1, 1983
    PubMed

    Insights

    This case report details Budd-Chiari syndrome with inferior vena cava obstruction, complicated by Sjögren's syndrome and chronic thyroiditis. A circulating anticoagulant caused prolonged activated partial thromboplastin time, suggesting interrelation between these conditions.

    Area of Science:

    • Vascular Medicine
    • Autoimmune Diseases
    • Endocrinology

    Background:

    • Budd-Chiari syndrome involves hepatic venous outflow obstruction, often idiopathic.
    • Sjögren's syndrome is a systemic autoimmune disorder affecting exocrine glands.
    • Chronic thyroiditis is an autoimmune condition impacting the thyroid gland.

    Observation:

    • A patient presented with Budd-Chiari syndrome and inferior vena cava obstruction.
    • The patient also had coexisting Sjögren's syndrome and chronic thyroiditis.
    • A significant prolongation of activated partial thromboplastin time was observed.

    Findings:

    • The prolonged activated partial thromboplastin time was attributed to a circulating anticoagulant.
    • This suggests a potential link between inferior vena cava thrombosis, circulating anticoagulants, and Sjögren's syndrome.
    • The interplay of autoimmune conditions and thrombotic events is highlighted.

    Implications:

    • This case suggests a possible association between Sjögren's syndrome and Budd-Chiari syndrome.
    • Further research may elucidate the role of circulating anticoagulants in autoimmune-related thrombosis.
    • Understanding these interrelations could inform diagnostic and therapeutic strategies for complex thrombotic disorders.

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