[Local experimental infection caused by S. epidermidis sensitive to penicillin under the action of the antibiotic and acridines]
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Abstract:
S. epidermidis D-5/48, D-5/240, and S. aureus 209 P caused a local infectious process with an analogous course in intrascrotal infection of male albino mice; this process was characterized by the changes of the relative weight coefficient of the affected tissues, positive staphylococcus culture, and exudative inflammation. This confirmed the role of epidermal coagulase-negative staphylococci in the infectious pathology. Benzylpenicillin treatment of local staphylococcus infection proved to be ineffective, although the staphylococcus strains used for the infection were sensitive to this antibiotic. This treatment led to the selection of the antibiotic-resistant forms of the microorganisms and to the aggravation of the infectious process, suggesting greater virulence of the antibiotic-resistant strains. The minimal suppressive acridines concentrations prevented the development of penicillin resistance and selection of resistant staphylococci, increased the therapeutic efficacy of this antibiotic.
Insights
Benzylpenicillin was ineffective against Staphylococcus infections in mice, leading to resistant strains. Acridines prevented resistance and enhanced benzylpenicillin
Area of Science:
- Microbiology and Infectious Diseases
- Pharmacology and Therapeutics
Context:
- Investigates the efficacy of benzylpenicillin in treating local Staphylococcus infections.
- Examines the development of antibiotic resistance and its impact on infection severity.
- Explores the potential of acridines in overcoming antibiotic resistance.
Purpose:
- To evaluate benzylpenicillin's effectiveness against Staphylococcus epidermidis and Staphylococcus aureus.
- To determine if benzylpenicillin treatment selects for antibiotic-resistant strains.
- To assess the role of acridines in preventing resistance and enhancing benzylpenicillin therapy.
Summary:
- Local Staphylococcus infections in mice treated with benzylpenicillin showed no improvement and led to the selection of resistant strains.
- These resistant strains exhibited increased virulence, worsening the infectious process.
- Co-administration of acridines prevented penicillin resistance and improved treatment outcomes.
Impact:
- Highlights the challenge of benzylpenicillin resistance in Staphylococcus infections.
- Suggests acridines as a potential strategy to combat antibiotic resistance.
- Provides insights into managing infectious pathologies caused by staphylococci.