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Plasma 11-deoxycortisol in normal and abnormal human pregnancy
American Journal of Obstetrics and Gynecology
|December 1, 1983
Summary
Maternal plasma 11-deoxycortisol levels rise during pregnancy, peaking at 39 weeks. Fetal or fetoplacental sources are likely responsible for this increase in 11-deoxycortisol during late gestation.
Area of Science:
- Endocrinology
- Reproductive Biology
- Maternal-Fetal Medicine
Background:
- 11-Deoxycortisol is a steroid hormone.
- Its role and source in maternal circulation during pregnancy are not fully understood.
Purpose of the Study:
- To investigate the source of 11-deoxycortisol in maternal plasma during pregnancy.
- To correlate 11-deoxycortisol levels with gestational progress and fetal status.
Main Methods:
- Assay of 11-deoxycortisol in maternal and cord plasma.
- Analysis of levels across different pregnancy stages, postpartum, and in specific fetal conditions.
Main Results:
- Maternal 11-deoxycortisol concentrations increased with gestational age, peaking at 39 weeks.
- Levels rapidly declined postpartum.
- Lower values were observed in intrauterine fetal death and anencephaly.
- Maternal levels were near normal in adrenalectomized women.
- Twin pregnancies showed elevated maternal levels.
Conclusions:
- The fetus or fetoplacental unit is the presumed source of elevated maternal 11-deoxycortisol in late pregnancy.
- 11-Deoxycortisol levels serve as a potential indicator of fetal well-being and placental function.