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Vaginal absorption of hexachlorophene during labor
American Journal of Obstetrics and Gynecology
|December 1, 1983
Summary
Hexachlorophene in surgical soap, used as a vaginal lubricant during labor, can be absorbed. Detectable levels were found in maternal and cord serum, raising concerns about potential neonatal toxicity.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Toxicology
- Pharmacokinetics
Background:
- Surgical soaps containing hexachlorophene are sometimes used as vaginal lubricants during labor.
- Concerns exist regarding potential fetal and neonatal toxicity due to hexachlorophene absorption from the vaginal mucosa.
Purpose of the Study:
- To evaluate the vaginal absorption and placental transfer of hexachlorophene.
- To quantify hexachlorophene levels in maternal and neonatal serum following labor.
Main Methods:
- Measured hexachlorophene levels in maternal and cord serum of 28 women.
- Participants' vaginal examinations were lubricated with pHisoHex during labor.
Main Results:
- Hexachlorophene was detected in the serum of 12 mothers (high: 942 ng/ml).
- Nine neonates had detectable levels in cord serum (high: 617 ng/ml).
- Variable absorption of hexachlorophene from the vaginal mucosa was observed.
Conclusions:
- Hexachlorophene from vaginal lubricants is absorbed variably and transfers to the fetus.
- Significant amounts detected in maternal and cord serum warrant caution.
- Alternative lubricants are recommended to prevent potential neonatal hexachlorophene toxicity.