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Mitral valve prolapse and agoraphobia.

M Mavissakalian, R Salerni, M E Thompson

The American Journal of Psychiatry

|December 1, 1983

Summary

Agoraphobia patients showed a low prevalence of mitral valve prolapse (15%). No significant differences were found between patients with or without mitral valve prolapse in demographics, clinical variables, or psychological symptoms post-treatment.

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Area of Science:

Psychiatry
Cardiology
Clinical Psychology

Background:

Agoraphobia is a complex anxiety disorder.
Mitral valve prolapse (MVP) has been anecdotally linked to anxiety disorders.
Previous research has explored the connection between MVP and agoraphobia.

Purpose of the Study:

To investigate the prevalence of mitral valve prolapse (MVP) in a cohort of female agoraphobic patients.
To determine if MVP influences demographic, clinical, or psychological characteristics of agoraphobia.
To assess treatment outcomes for agoraphobia in patients with and without MVP.

Main Methods:

A cohort of 46 female patients diagnosed with agoraphobia was assessed.
Prevalence of definite and probable mitral valve prolapse (MVP) was determined.
Demographic, clinical, and psychological symptom measures were collected before and after treatment.
Statistical analyses compared patients with MVP to those without.

Main Results:

The overall prevalence of mitral valve prolapse (MVP) was 15% (3 definite, 4 probable cases).
No significant differences were observed in demographic or clinical variables between patients with and without MVP.
Psychological symptom measures showed no significant differences between groups before or after treatment.

Conclusions:

The prevalence of mitral valve prolapse (MVP) in this agoraphobic sample is low.
Agoraphobia associated with mitral valve prolapse appears clinically indistinguishable from agoraphobia without MVP.
These findings suggest MVP may not be a significant differentiating factor in agoraphobia.

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