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Related Experiment Videos

Pre-operative peroral zinc supplementation.

T Hallböök, H Hedelin

    Acta Chirurgica Scandinavica
    |January 1, 1978
    PubMed
    Summary

    Pre-operative zinc supplementation in surgical patients increased serum zinc levels. While it did not reduce the post-operative drop, it prevented levels from falling below the initial baseline.

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    Area of Science:

    • Surgical Nutrition
    • Trace Element Metabolism
    • Clinical Chemistry

    Background:

    • Surgical stress can deplete essential nutrients like zinc.
    • Maintaining adequate zinc levels is crucial for wound healing and immune function.
    • Pre-operative nutritional status can impact post-operative recovery.

    Purpose of the Study:

    • To investigate the effect of oral zinc supplementation before surgery on serum zinc concentrations.
    • To determine if pre-operative zinc affects the magnitude of post-operative serum zinc decline.
    • To assess the impact of zinc supplementation in different patient subgroups.

    Main Methods:

    • 37 adult surgical patients received oral zinc supplementation pre-operatively.
    • Serum zinc concentrations were monitored for five days post-surgery.
    • Statistical analysis was used to compare pre- and post-operative zinc levels.

    Main Results:

    • Pre-operative zinc treatment significantly increased serum zinc levels (15.5 to 18.7 mumol/l, p < 0.001).
    • The post-operative decline in serum zinc magnitude was not reduced by supplementation.
    • Mean post-operative serum zinc did not fall below pre-operative levels in the general patient group.
    • The beneficial effect of zinc was less pronounced in elderly patients, particularly after transvesical prostatectomy.

    Conclusions:

    • Pre-operative oral zinc supplementation effectively raises serum zinc levels in surgical patients.
    • Supplementation helps maintain post-operative serum zinc above pre-operative levels, though the drop's magnitude is unchanged.
    • Elderly patients and those undergoing specific procedures may have a diminished response to pre-operative zinc supplementation.

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