[Bioavailability of levomycetin preparations for oral use]

Bioavailability of chloramphenicol pharmaceutical forms prepared with the use of antibiotic substances differing in their dispersion levels was studied. It was shown that the level and rate of the drug absorption into blood did not always depend on the size of the substance particles. Fine crystalline substances of the antibiotic manufactured by two firms almost not differing in their dispersion levels markedly differed in the rate of antibiotic transfer into solution and the level of its blood absorption in humans. Tablets prepared with the use of the above substances were also characterized by various bioavailability levels. Study of the dissolution rate of separate fractions of the same substance revealed dependence of this parameter on the particle size.