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Cows' milk hypersensitivity: immediate and delayed onset clinical patterns.

R P Ford, D J Hill, C S Hosking

    Archives of Disease in Childhood
    |November 1, 1983
    PubMed
    Summary
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    Adverse reactions to cows' milk hypersensitivity in children present in two distinct patterns: immediate onset with skin symptoms and delayed onset with gastrointestinal issues. Categorizing these reactions improves diagnostic accuracy for milk allergies.

    Area of Science:

    • Pediatric Allergy and Immunology
    • Clinical Nutrition
    • Immunology

    Background:

    • Adverse reactions to cows' milk are common in infants and children.
    • Understanding the clinical patterns of these reactions is crucial for accurate diagnosis and management.
    • Previous studies have suggested different types of reactions, but clear categorization is needed.

    Purpose of the Study:

    • To investigate and categorize the clinical patterns of adverse reactions to cows' milk in children.
    • To differentiate between immediate and delayed onset reactions based on clinical manifestations and immunological markers.
    • To enhance the reliability of diagnostic tools like milk prick tests.

    Main Methods:

    • A study involving 72 children diagnosed with cows' milk hypersensitivity.

    Related Experiment Videos

  • Classification of reactions into two groups: immediate onset (within 1 hour) and delayed onset (after 1 hour).
  • Assessment of clinical symptoms (cutaneous, gastrointestinal), prick test results, IgE levels, atopy status, and provocation dose.

    • Main Results:

    • Immediate onset reactions were associated with cutaneous symptoms, positive prick tests, elevated IgE, atopy, and sensitivity to small milk amounts.
    • Delayed onset reactions typically presented with gastrointestinal symptoms, negative prick tests, normal IgE, non-atopic status, and required larger milk quantities for reaction.
    • Distinct clinical and immunological profiles were observed for each group.

    Conclusions:

    • Cows' milk hypersensitivity can be broadly classified into immediate and delayed onset reaction types.
    • This categorization aids in interpreting clinical findings and milk prick test results more reliably.
    • Differentiating these patterns can lead to improved diagnostic strategies and patient management.