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[Selenium compounds and carcinogenesis].

G Seidel

    Archiv Fur Geschwulstforschung
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Selenium compounds are essential trace elements with toxic effects. Research explores their influence on cancer development and potential for chemoprevention, but current data is insufficient to confirm efficacy.

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    Area of Science:

    • Biochemistry
    • Toxicology
    • Oncology

    Context:

    • Selenium is a vital trace element with known toxic effects.
    • Understanding selenium's mechanism of action is crucial for biological and medical applications.
    • Malignant transformation and tumor development are complex processes influenced by various factors.

    Purpose:

    • To survey the influence of selenium compounds on malignant transformation in vitro and in vivo.
    • To review the effects of selenium compounds on different types of tumors.
    • To analyze hypotheses regarding the mechanism of action of selenium and its compounds.

    Summary:

    • This review outlines the general toxic effects and biological importance of selenium compounds as a trace element.
    • It examines how selenium compounds may affect malignant transformation and related processes, both in laboratory settings and living organisms.

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  • The effects of selenium compounds on spontaneous, chemically induced, and virally induced tumors are discussed.

    • Impact:

    • Current data is insufficient to determine if selenium compounds can be used for cancer chemoprevention.
    • Further research is needed to elucidate the precise role of selenium in cancer development and prevention.
    • This work provides a foundation for future investigations into selenium's therapeutic potential in oncology.