Beta-glucuronidase of lymphocytes in ontogenetic development of man

The activity and intracellular localization of lysosomal acid phosphatase in lymphocytes was studied in 170 healthy subjects of various age using semiquantitative cytochemical method. The groups studied included the premature and term infants, children and adults. During fetal development the gradual organization of enzyme-positive lysosomal granules within lymphocytes occurs and subsequent five decades of life are characterized by stabilization of lysosomal apparatus of these cells. In last decades of life, between 60 and 90, the destabilization and destruction of acid-phosphatase-positive lysosomal granules is observed.