Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human pituitary tumors with two cell lines.

M Anniko, B Tribukait, J Wersäll

    Archives of Oto-Rhino-Laryngology
    |January 1, 1983
    PubMed
    Summary

    Pituitary tumors can have multiple cell lines, particularly those causing acromegaly. Tumors secreting growth hormone (GH) and prolactin (PRL) showed a higher incidence of biclonal cell lines.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Release of epidermal growth-factor transforming growth-factor-alpha by ovarian-tumors in-vitro.

    International journal of oncology·2011
    Same author

    Steroid-hormone production and receptors in relation to ki-67, p53, s-phase fraction and ploidy in epithelial ovarian-tumors.

    International journal of oncology·2011
    Same author

    Hair cell damage in the inner ear of the Guinea pig due to noise in a workshop.

    Acta oto-laryngologica·2011
    Same author

    Diagnostic and prognostic implications of DNA ploidy and S-phase evaluation in the assessment of malignancy in biliary strictures.

    Endoscopy·2006
    Same author

    Colorectal cancer in colonic Crohn's disease--high frequency of DNA-aneuploidy.

    Anticancer research·2005
    Same author

    Low IL-1alpha expression in bladder cancer tissue and survival.

    European urology·2003

    Area of Science:

    • Endocrinology
    • Oncology
    • Cell Biology

    Background:

    • Pituitary tumors are neoplasms originating from the pituitary gland.
    • Acromegaly results from excessive growth hormone (GH) secretion.
    • Co-secretion of GH and prolactin (PRL) can occur in pituitary adenomas.

    Purpose of the Study:

    • To investigate the cellular composition of pituitary tumors.
    • To determine the frequency of multiple cell lines in pituitary adenomas.
    • To correlate the presence of multiple cell lines with specific hormone secretion profiles.

    Main Methods:

    • Analysis of 47 pituitary tumor samples.
    • Identification and characterization of cell lines within tumors.
    • Correlation of cell line number with hormone secretion (GH, PRL) and clinical presentation (acromegaly).
    • Morphological assessment of cell populations.

    Main Results:

    • Out of 47 pituitary tumors, 42 had a single cell line and five had two cell lines.
    • Biclonal cell lines were observed in tumors causing acromegaly.
    • Tumors with concomitant GH and PRL secretion exhibited a higher proportion of biclonal cell lines (46%) compared to GH-secreting tumors (20%).
    • Morphological distinction between cell populations was rare.

    Conclusions:

    • Pituitary tumors, especially those associated with acromegaly and co-secreting GH and PRL, can exhibit multiple cell lines.
    • The presence of biclonality may be linked to specific secretory phenotypes.
    • Further research is needed to understand the implications of multiple cell lines in pituitary tumorigenesis.

    Related Experiment Videos