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On receptors for estrogens (E2) and androgens (DHT) in human endometrial carcinoma and ovarian tumours

L G Friberg, S Kullander, J P Persijn

    Acta Obstetricia Et Gynecologica Scandinavica
    |January 1, 1978
    PubMed

    Insights

    Endometrial carcinomas show varying patterns of estrogen (E2) and dihydrotestosterone (DHT) receptors. Receptor presence correlates with tumor differentiation and stage, impacting potential hormonal treatment strategies for this cancer.

    Area of Science:

    • Oncology
    • Endocrinology
    • Molecular Biology

    Background:

    • Endometrial carcinomas can express receptors for estrogen (E2) and dihydrotestosterone (DHT).
    • The presence and pattern of these receptors in tumors are not fully understood.
    • Receptor status may influence tumor behavior and treatment response.

    Purpose of the Study:

    • To analyze the receptor patterns of estrogen (E2) and dihydrotestosterone (DHT) in primary endometrial carcinomas.
    • To correlate receptor status with tumor differentiation and clinical stage.
    • To explore the implications for hormonal therapy in endometrial cancer.

    Main Methods:

    • Agar gel electrophoresis was used to analyze receptor patterns.
    • Fifty primary endometrial carcinomas were examined.
    • Receptor presence was assessed in relation to tumor differentiation and stage (II-IV).

    Main Results:

    • Varying patterns of E2 and DHT receptors were observed, including absence, sole presence, or combined presence.
    • Highly differentiated tumors frequently possessed both E2 and DHT receptors (7/18).
    • Poorly differentiated tumors and those with metastases (Stages III-IV) or cervical invasion (Stage II) often lacked combined receptors.

    Conclusions:

    • Receptor patterns for E2 and DHT vary significantly in endometrial carcinomas.
    • Tumor differentiation and stage are associated with the presence of combined E2 and DHT receptors.
    • These findings may inform the selection of hormonal treatments for endometrial cancer.

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