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Coronary collateral development in the rhesus monkey (Macaca mulatta).

D D Buss, D M Hyde, E P Steffey

    Basic Research in Cardiology
    |September 1, 1983
    PubMed
    Summary
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    Rhesus monkeys struggle to develop coronary collaterals. Gradual coronary artery occlusion led to myocardial infarction, indicating insufficient collateral blood flow in this species.

    Area of Science:

    • Cardiovascular Science
    • Primate Research
    • Ischemic Heart Disease Models

    Background:

    • Coronary collateral circulation is vital for preventing myocardial infarction during gradual coronary artery occlusion.
    • Understanding interspecies differences in collateral development is crucial for preclinical research.

    Purpose of the Study:

    • To investigate the capacity of rhesus monkeys to form coronary collaterals following induced gradual coronary artery occlusion.
    • To assess the functional significance of collateral development in preventing myocardial damage.

    Main Methods:

    • Ten rhesus monkeys underwent ameroid constrictor implantation on the left circumflex coronary artery for 12 weeks.
    • Hearts were analyzed post-mortem using perfusion fixation and barium-gelatin coronary vascular injection.

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  • Myocardial infarction was assessed histologically.

    • Main Results:

    • All surviving animals exhibited infarction scars in the affected coronary artery regions.
    • Coronary collaterals were infrequent, small, and primarily observed in the atria.
    • One animal succumbed to acute myocardial infarction early in the study.

    Conclusions:

    • Rhesus monkeys demonstrate a limited ability to form functional coronary collaterals.
    • This species is unable to develop sufficient collateral blood flow to prevent myocardial infarction from gradual, total coronary occlusion.